The Stranglethorn Vale is a vast jungle south of Duskwood.

Jungle trolls patrol this steaming rainforest. Ancient Gurubashi trolls once ruled the region, and the ruins of their great cities crumble in the jungle's heat and growth. Naga hunt along the coast and vicious animals and plants, including the eponymous strangle-thorns, make travel dangerous. The Arena, a center for gladiatorial games set in a ruined Gurubashi fighting stadium, draws shady characters of all races. The Blackwater Raiders, a vile group of pirates, make their home in Booty Bay, on the Stranglethorn's southern coast.

The Vale was the primary center of the trolls of the Gurubashi Empire, and their cities were dotted all over the region. After the Empire's fall the cities of the troll empire fell into ruin, although they are still populated by trolls. In recent years, the Humans of Stormwind attempted to forge trade routes through this savage jungle. Though they managed to establish the small port town of Blackwater Cove, they were quickly overwhelmed by a crazed pack of Trolls and driven back to their homeland. In the wake of the Humans' departure, the crafty Goblin Trade Princes arrived on the jungle's shores and quickly set up their mining and deforesting operations. The Goblins have maintained a tenuous hold over these remote facilities, but they remain threatened by the Jungle Trolls' growing obsession with purging their ancient lands of any and all foreign invaders.

Stranglethorn is as deadly as it is beautiful. It is inhabited by a large variety of beasts and hostile creatures that low level characters should not face alone. The primary sentient inhabitants are the Bloodscalp and Skullsplitter trolls, in the northwest and east respectively. The troll city of Zul'Gurub sits in a valley in the northeast, which was once the capital of Troll civilization in Stranglethorn. In the north is a small village controlled by the renegade Colonel Kurzen. Other inhabitants include an encampment of ogres. Off the southeast coast is Jaguero Isle, inhabited by the enormous gorilla King Mukla. There is a renegade group of sailors, known as the Bloodsail Buccaneers, who have built camps on the southwestern and southern shores of Stranglethorn Vale. A small population of Naga can be found in the southwest, and murlocs inhabit some underwater ruins in the northwest. The Venture Company also has two mining operations in Stranglethorn. In the northwest, the Zandalar Tribe has its base in Yojamba Isle. The Water Gate from Deadmines can also been seen north of Yojamba Isle, though it cannot be entered.

Stranglethorn Vale has for millennia been the home of the jungle trolls, under the leadership of the Gurubashi tribe. Over time, the Gurubashi came to be unduly cruel, sacrificing trolls of other tribes to their evil god Hakkar the Soulflayer. After an extensive civil war, the tribes of Stranglethorn split, forever becoming enemies. The Darkspear tribe was one of these tribes, eventually driven offshore by a band of rampaging murlocs and taken in by the Horde. To this day, Stranglethorn remains a wild place full of danger.