Azuremyst Isle is one of the two main islands that make up the Azuremyst Isles. It is the island least affected by the crystalline shards. Remaining mostly untouched by sapient races until recently, the land has changed a great deal due to the recent crash by a draenei inter-dimensional generation ship. Powerful and ominous crystals dot the lands, and energy storms ripple through the sky. The draenei capital city, The Exodar, is built around their crashed ship in the western part of Azuremyst Isle.

Evidence that parts of the crashed ship are tainting and mutating the natural flora and fauna of the island has become apparent. The draenei are working to halt and, if possible, reverse these mutations as soon as possible to restore the natural beauty and health of the island.

Azuremyst Isle, one of WoW's starting zones, sees the least amount of PvP action (along with Teldrassil) due to the fact that the only way for Horde players to get to Azuremyst Isle itself is via ship from Rut'theran Village on mainland Teldrassil. Other starting zones are directly accessible by the opposing faction without such hazards.

Very little history is known of Azuremyst Isle and the surrounding islands. Not visited often by the night elves and tauren of Kalimdor due to their out-of-the-way location, the isles' indigenous creatures have been left to their own devices over the centuries. This is also the reason why the other races have not yet noticed the crashed dimensional ship that lies scattered across the islands, now used by the surviving draenei as a set of bases and outposts.

Some civilization did exist on the island before the draenei arrived. On the southern Silvermyst Isle, a dock and house of night elf architecture marks the dwelling of a family of night elves who made their home here. In addition, a clan of furbolgs live in the central island. Due to being so far removed from their cousins in Kalimdor, these furbolgs have remained uncorrupted, though they have recently been driven out of their ancestral holdings.

Additionally, ancient night elven ruins predating the Sundering are found scattered about both Azuremyst and Bloodmyst, all of them now inhabited by vile naga. The night elves have mostly abandoned these islands in favor of mainland Kalimdor.